It can improve the slow transit constipation reaction, increase the water content of feces, improve the intestinal transit rate, and does not produce drug resistance or cause adverse reactions in patients. It can be used to prepare products for improving the treatment of constipation. In addition, BLa36 can regulate intestinal flora, increase the alpha diversity of intestinal flora, and increase the relative abundance of beneficial bacteria.

Animal experiment results show that BBi32 can increase the overall content of short-chain fatty acids in the intestines of mice, thereby reducing the pH value of the intestinal environment, and has obvious properties of repairing colon mucosal damage, achieving the purpose of relieving constipation.

It has good tolerance to gastrointestinal juices and can smoothly reach the intestine. It can consume free oxygen in the intestine, making the intestinal environment conducive to the growth of anaerobic strains such as Lactobacillus and Bifidobacterium, and increasing the number of probiotic strains.

Helps improve the diversity and richness of intestinal flora, regulates intestinal flora, and relieves constipation. At the same time, BL21 has strong acid and bile salt resistance and free radical ability, and can exert antioxidant and other functions.

Animal experiments show that Lp18 can significantly increase the number of defecation particles and fecal water content in constipated mice, improve the levels of gastrointestinal regulatory peptides in constipated mice, thereby promoting gastric acid secretion in mice, accelerating gastric emptying, accelerating intestinal transit rate, and effectively improving and relieving defecation in constipated mice.