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Home > Products > WecLac^® Individual Clinical Strains > Lacticaseibacillus paracasei

Lacticaseibacillus paracaseiLC86

Potency

600B CFU/g

Source of Strain

Handmade yogurt

Deposit Number

PTA-126816(ATCC) No.1.12731(CGMCC)

Functions

Gastrointestinal Health
Metabolic Health
Emotional Health
Maternal & Child Health
Immune Health
Oral Health

References

[1]Dong Y, Han M, Fei T, Liu H, Gai Z. Utilization of diverse oligosaccharides for growth by Bifidobacterium and Lactobacillus species and their in vitro co-cultivation characteristics. Int Microbiol. 2023 Nov 9. doi: 10.1007/s10123-023-00446-x. Epub ahead of print. PMID: 37946011.

[2]Rui W, Zhong S, Li X, Tang X, Wang L, Yang J. Evaluating the Role of Postbiotics in the Modulation of Human Oral Microbiota: A Randomized Controlled Clinical Trial. Probiotics Antimicrob Proteins. 2024 Mar 19. doi: 10.1007/s12602-024-10238-y. Epub ahead of print. PMID: 38502383.

[3]Cai Y, Dong Y, Han M, Jin M, Liu H, Gai Z, Zou K. Lacticaseibacillus paracasei LC86 mitigates age-related muscle wasting and cognitive impairment in SAMP8 mice through gut microbiota modulation and the regulation of serum inflammatory factors. Front Nutr. 2024 May 30;11:1390433. doi: 10.3389/fnut.2024.1390433. PMID: 38873561; PMCID: PMC11169942.

[4]Application of Lactobacillus paracasei in the preparation of products to alleviate anxiety and depression symptoms(ZL 202210409422.9)

Introduction

This study investigates the potentia benefits of Lacticaseibacillus paracaseiLC86 on age-related muscle wasting and cognitive decline using the senescence-accelerated mouse prone 8 (SAMP8) model, aiming to elucidate its effects and mechanisms for therapeutic applications.

Study Design

Main Results

LC86 attenuated the senescence scores,sug-gesting LC86 reduced thesigns of aging in the body

lmmune Health

LC86 enhanced forelimb grip strength, reduced inage-correlated holding fatigue, and elevated themuscular glycogen levels, indicating LC86 couldimprove the muscle strength

LC86 improved the cognitive performance

LC86 increased the beneficial bacteria

Conclusion

LC86 ameliorates agerelated muscle wasting and cognitive impairment in SAMP8 mice through multiple pathways, suggesting it is a potentia therapeutic agent for age-related sarcopenia and cognitive impairment and provide directions for its further clinical research and application.

Figure 1. Experimental design, change in body weight of SAlP8 mice, and senescence score, The experimental intervention period was 12 weeks using Lacticaseibacilus paracasei LC86 (A); body weight was measured from week 1 to week 12 (B); senescence score (C) wasmeasured before and at the end of the experiment.

Figure 2. Lacticaseibacilus paracasei LC86 improved muscle strength in SAMP8 mice. Effect ofLC86 on forelimb grip strength (A), limb catching ability (B), and muscle glycogen content (C) in gastrocnemius muscle of SAMP8 mice, The corelation between the glycogen level in the gastrocnemius muscle and the forelimb grasping force (D) and the ability to catch the limbs (E) was analyzed in the mice.

Figure 3. Lacticaseibacilus paracasei LC86 improved the cognitive performance of SAMP8 mice.lin open-field experiments, LC86 improved the mice's locomotor distance (A) and awell time in the central region (8).,LC86 decreased the delay in reaching the platform in the water maze experiment in mice (Cy. LC86 significantly increased dopamine (D) and serotonin (E) levels in mouse hippocampus and dopamine (F) and serotonin (G) levels in striatum.

Figure 4. Lacticaseibacilus paracasei LC86 improved serum inflammatory response and increased liver antioxidant capacity in SAMP8 mice.Effect of LC86 on serum tumor necrosis factor a (A), interleukin 6 (B), monocyte chemoatractant protein-1 (C), and interleukin 10 (D). Efect of LC86 on liver peroxidase activity (El,glutathione level (F), contact enzyme activity (G), and malondialdehvdelevel (H), Dihvdroethidine staining was performed to investigate the effect of LC86 on reactive oxygen species in the liver.

Figure 5. Modulation ofthe gut microbiota by Lacticaseibacillus paracasei LC86. The effect of LC86 on the alpha diversity of the gut microbiota was assessed by Chaol index (A) and Shannon index (B), and the effect of LC86 on the beta diversity of the qut microbiota was analyzed by PCoA. Species with significant diferences in abundance in diferent groups were examined using LEfSe analysis (D), and the association oihese species with metadata (E) was assessed, TNF a , tumor necrosis factor a: ll6,interleukin 6: L10,interleukin 10: MCP-1. monocyte chemoattractant protein-1; SOD, superoxide dismutase; CAT, catalase; GSH, glutathione; MDA, malondialdehyde; DA, dopamine, HT, serotonin(5-HT).