WecLac® Strains
Clinically Studied
SCI/Patent Supported
SCI/Patent Supported
Bifidobacterium longum subsp. longumBL21
Potency
300B CFU/g
Source of Strain
Healthy infant intestines
Deposit Number
PTA-126818(ATCC) No.10452(CGMCC)
Functions
-
Gastrointestinal Health -
Metabolic Health -
Emotional Health -
Maternal & Child Health -
Immune Health -
Oral Health
References
[1]Wu T, Sun M, Liu R, Sui W, Zhang J, Yin J, Fang S, Zhu J, Zhang M. Bifidobacterium longum subsp. longum Remodeled Roseburia and Phosphatidylserine Levels and Ameliorated Intestinal Disorders and liver Metabolic Abnormalities Induced by High-Fat Diet. J Agric Food Chem. 2020 Apr 22;68(16):4632-4640. doi: 10.1021/acs.jafc.0c00717. Epub 2020 Apr 10. PMID: 32237746.
[2]Zhao TS, Xie LW, Cai S, Xu JY, Zhou H, Tang LF, Yang C, Fang S, Li M, Tian Y. Dysbiosis of Gut Microbiota Is Associated With the Progression of Radiation-Induced Intestinal Injury and Is Alleviated by Oral Compound Probiotics in Mouse Model. Front Cell Infect Microbiol. 2021 Oct 25;11:717636. doi: 10.3389/fcimb.2021.717636. PMID: 34760714; PMCID: PMC8573182.
[3]Hao J, Zhang Y, Wu T, Liu R, Sui W, Zhu J, Fang S, Geng J, Zhang M. The antidiabetic effects of Bifidobacterium longum subsp. longum BL21 through regulating gut microbiota structure in type 2 diabetic mice. Food Funct. 2022 Oct 3;13(19):9947-9958. doi: 10.1039/d2fo01109c. PMID: 36056711.
[4]Ye Z, Liang L, Xu Y, Yang J, Li Y. Probiotics Influence Gut Microbiota and Tumor Immune Microenvironment to Enhance Anti-Tumor Efficacy of Doxorubicin. Probiotics Antimicrob Proteins. 2023 Apr 11. doi: 10.1007/s12602-023-10073-7. Epub ahead of print. PMID: 37040014.
[5]Gai Z, Liao W, Huang Y, Dong Y, Feng H, Han M. Effects of Bifidobacterium BL21 and Lacticaseibacillus LRa05 on gut microbiota in type 2 diabetes mellitus mice. AMB Express. 2023 Sep 16;13(1):97. doi: 10.1186/s13568-023-01603-1. PMID: 37716924; PMCID: PMC10505128.
[6]Dong Y, Wu Z, Gai Z, Han M. Bifidobacterium longum subsp. longum BL21 ameliorates alcoholic liver disease in mice through enhancement of the hepatic antioxidant capacity and modulation of the gut microbiota. J Appl Microbiol. 2023 Nov 1;134(11):lxad251. doi: 10.1093/jambio/lxad251. PMID: 37930723.
[7]Dong Y, Han M, Fei T, Liu H, Gai Z. Utilization of diverse oligosaccharides for growth by Bifidobacterium and Lactobacillus species and their in vitro co-cultivation characteristics. Int Microbiol. 2023 Nov 9. doi: 10.1007/s10123-023-00446-x. Epub ahead of print. PMID: 37946011.
[8]Dong Y, Gai Z, Han M, Xu J, Zou K. Reduction in Serum Concentrations of Uremic Toxins Driven by Bifidobacterium Longum Subsp. Longum BL21 is Associated with Gut Microbiota Changes in a Rat Model of Chronic Kidney Disease. Probiotics Antimicrob Proteins. 2024 Jun 3. doi: 10.1007/s12602-024-10293-5. Epub ahead of print. PMID: 38829564.
Introduction
Weight management
The results of the present study suggested that BL21 could improve TC, TG, and LDL-C in the mice with an HFDdiet. The decrease in the size of epididymal fat cells can directly show that BL21 positively affects the ameliorationof obesity in mice, and the liver tissue of the BL21 group was protected as well.
Intervention with BL21 significantly reduces weight gain and abnormal blood lipid levels
Anti-aging
The extracelular polysaccharide produced by BL21 can significantly reduce the fommation of melanin in B16 cellsat specific concentrations, for example, it can reduce the melanin formation rate by up to 50% at a concentration of3.3mg/ml.
Comparison of electron microscopic pictures of extracellular polysaccharide produced by BL21 and control strain
BL21 has a relatively balanced ability to scavenge superoxide radicals, hydroxyl radicals, and superoxide dismutase activity
Extracellular polysaccharides produced by BL21 brings improvement for stains, chloasma and melanin
BL21 can improve the survival rate of irradiated mice, reduce intestinal damage and restore the diversity of intestinal flora
BL21 has excellent tolerance and stability
Improve liver metabolism
To assess liver injury, levels of liver enzymes, plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST), were measured.
According to the control group, the mice in the AF group significantly increased the levels of plasma ALT and AST dueto alcohol exposure, while probiotic intervention could reverse this situation sianificantly, was basically able to return tonormal levels and alleviated chronic alcohol-induced liver damage.
According to the control group, the hepatic triglyceride content of the AF group was significantly increased, whilechronic alcohol-induced hepatic triglyceride accumulation was reduced, and the compound probiotic group had thebest effect after probiotic intervention. in addition, long-term exposure to alcohol increases plasma and hepatic FFAlevels, and probiotic intervention can halt this trend, especially the compound probiotic group, it means probioticintervention can effectively reduce chronic alcohol-induced hepatic lipid accumulation and liver injury.
Specialization Advantages
40,000+ Strain Resources
GRAS certified
Allergen free
SCI / Patent supported
High survivability
Non-GMO verified
Clinically studied
High colonisation
Precise function
Industrialization Advantages
High potency
Low water activity
Cost-effectiveness
High stability
Fast delivery
cGMP standard
Excellent batch stability
Stable supply chain
Advanced equipment
Application
-
Dietary Supplement -
Food -
Dairy -
Precision Medicine -
Personal Care -
Feed Additive/Pet
WecLac® Strains
No. 999, Guangming Rd., Wujiang Economic and Technological Development Zone,
Suzhou City, Jiangsu Province, China