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Home > Products > WecLac^® Individual Clinical Strains > Bifidobacterium longum subsp. longum

Bifidobacterium longum subsp. longumBL21

Potency

300B CFU/g

Source of Strain

Healthy infant intestines

Deposit Number

PTA-126818(ATCC) No.10452(CGMCC)

Functions

Gastrointestinal Health
Metabolic Health
Emotional Health
Maternal & Child Health
Immune Health
Oral Health

References

[1]Wu T, Sun M, Liu R, Sui W, Zhang J, Yin J, Fang S, Zhu J, Zhang M. Bifidobacterium longum subsp. longum Remodeled Roseburia and Phosphatidylserine Levels and Ameliorated Intestinal Disorders and liver Metabolic Abnormalities Induced by High-Fat Diet. J Agric Food Chem. 2020 Apr 22;68(16):4632-4640. doi: 10.1021/acs.jafc.0c00717. Epub 2020 Apr 10. PMID: 32237746.

[2]Zhao TS, Xie LW, Cai S, Xu JY, Zhou H, Tang LF, Yang C, Fang S, Li M, Tian Y. Dysbiosis of Gut Microbiota Is Associated With the Progression of Radiation-Induced Intestinal Injury and Is Alleviated by Oral Compound Probiotics in Mouse Model. Front Cell Infect Microbiol. 2021 Oct 25;11:717636. doi: 10.3389/fcimb.2021.717636. PMID: 34760714; PMCID: PMC8573182.

[3]Hao J, Zhang Y, Wu T, Liu R, Sui W, Zhu J, Fang S, Geng J, Zhang M. The antidiabetic effects of Bifidobacterium longum subsp. longum BL21 through regulating gut microbiota structure in type 2 diabetic mice. Food Funct. 2022 Oct 3;13(19):9947-9958. doi: 10.1039/d2fo01109c. PMID: 36056711.

[4]Ye Z, Liang L, Xu Y, Yang J, Li Y. Probiotics Influence Gut Microbiota and Tumor Immune Microenvironment to Enhance Anti-Tumor Efficacy of Doxorubicin. Probiotics Antimicrob Proteins. 2023 Apr 11. doi: 10.1007/s12602-023-10073-7. Epub ahead of print. PMID: 37040014.

[5]Gai Z, Liao W, Huang Y, Dong Y, Feng H, Han M. Effects of Bifidobacterium BL21 and Lacticaseibacillus LRa05 on gut microbiota in type 2 diabetes mellitus mice. AMB Express. 2023 Sep 16;13(1):97. doi: 10.1186/s13568-023-01603-1. PMID: 37716924; PMCID: PMC10505128.

[6]Dong Y, Wu Z, Gai Z, Han M. Bifidobacterium longum subsp. longum BL21 ameliorates alcoholic liver disease in mice through enhancement of the hepatic antioxidant capacity and modulation of the gut microbiota. J Appl Microbiol. 2023 Nov 1;134(11):lxad251. doi: 10.1093/jambio/lxad251. PMID: 37930723.

[7]Dong Y, Han M, Fei T, Liu H, Gai Z. Utilization of diverse oligosaccharides for growth by Bifidobacterium and Lactobacillus species and their in vitro co-cultivation characteristics. Int Microbiol. 2023 Nov 9. doi: 10.1007/s10123-023-00446-x. Epub ahead of print. PMID: 37946011.

[8]Dong Y, Gai Z, Han M, Xu J, Zou K. Reduction in Serum Concentrations of Uremic Toxins Driven by Bifidobacterium Longum Subsp. Longum BL21 is Associated with Gut Microbiota Changes in a Rat Model of Chronic Kidney Disease. Probiotics Antimicrob Proteins. 2024 Jun 3. doi: 10.1007/s12602-024-10293-5. Epub ahead of print. PMID: 38829564.

Introduction

Weight management

The results of the present study suggested that BL21 could improve TC, TG, and LDL-C in the mice with an HFDdiet. The decrease in the size of epididymal fat cells can directly show that BL21 positively affects the ameliorationof obesity in mice, and the liver tissue of the BL21 group was protected as well.

Intervention with BL21 significantly reduces weight gain and abnormal blood lipid levels

Anti-aging

The extracelular polysaccharide produced by BL21 can significantly reduce the fommation of melanin in B16 cellsat specific concentrations, for example, it can reduce the melanin formation rate by up to 50% at a concentration of3.3mg/ml.

Comparison of electron microscopic pictures of extracellular polysaccharide produced by BL21 and control strain

BL21 has a relatively balanced ability to scavenge superoxide radicals, hydroxyl radicals, and superoxide dismutase activity

Extracellular polysaccharides produced by BL21 brings improvement for stains, chloasma and melanin

BL21 can improve the survival rate of irradiated mice, reduce intestinal damage and restore the diversity of intestinal flora

BL21 has excellent tolerance and stability

Improve liver metabolism

To assess liver injury, levels of liver enzymes, plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST), were measured.
According to the control group, the mice in the AF group significantly increased the levels of plasma ALT and AST dueto alcohol exposure, while probiotic intervention could reverse this situation sianificantly, was basically able to return tonormal levels and alleviated chronic alcohol-induced liver damage.

According to the control group, the hepatic triglyceride content of the AF group was significantly increased, whilechronic alcohol-induced hepatic triglyceride accumulation was reduced, and the compound probiotic group had thebest effect after probiotic intervention. in addition, long-term exposure to alcohol increases plasma and hepatic FFAlevels, and probiotic intervention can halt this trend, especially the compound probiotic group, it means probioticintervention can effectively reduce chronic alcohol-induced hepatic lipid accumulation and liver injury.

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