Relieve hyperglycemia

The fasting blood glucose level is a very important indicator for the diagnosis of type ll diabetes. The fasting blood glucose concentration of mice was detected before and after the intervention. One week after the intraperitoneal injection of STZ, that is, at the 4th week, the fasting blood alucose in all aroups exceot the normal control aroup was sianificantiy increased (p<0.05), indicating that the model was successful. After 28 davs of self intervention, blood alucose levels in mice of diferent pre treatment groups decreased to varying degrees. Among them, pioglitazone, as a therapeutic drug for type ll diabetes, can efectively reduce the blood sugar level of mice by reducing insulin resistance, inhibiting the production of glucose in the liver and improving the utilization of glucose in peripheral tissues.

Cytokines play an important role in diabetes caused by inflammation and immunity. High fat diet can lead to proinflamma-tory factors such as TNF- a The increase in insulin resistance can lead to insulin resistance. in contrast, lL-10, as an anti-inflammatory cytokine, can inhibit antigen presentation and the production of inflammatory cvtokines such as TNF-a. In addition, oxidative stress also plavs an important role in the etiology of complications of diabetes, Generally, there are antioxidant substances such as SOD in cells, which can efectively eliminate harmful free radicals, thus effectively protect-ing cells from damage.

Relieve non-alcoholic fatty liver disease

The levels of ALT, AST, TC, and TG mentioned in the present invention can reduce serum inflammatory factors, reduce liver cell sweling, reduce the number of fat vacuoles, and increase the content of isobutyric acid and butyric acid in the intestine.which has a very broad application prospect.

Schematic diagram of weight changes

Comparison of liver tissue after HE staining

Schematic diagram of changes in the content of isobutyric acid and butyric acid in the feces of experimental rats after 14 weeks of intervention with composite probiotics; The letters in the box plot indicate significant differences between groups (P<0.05).

Lp90 has a high bile salt hydrolytic enzyme activity, can decompose bile acid emulsified fat, thereby reducing the body's absorption of fat, and has the effect of inhibiting fat accumulation.

According to the results, female volunteers accounted for the larger portion that found defecation discipline, frequency and stool smell, color were modified after supplied synbiotics for 20 days.While more male volunteers discovered their diarrhea problems declined and gut became relaxed.

The intervention of Lp90 can significantly reduce serum total cholesterol levels.

Lowering Cholesterol

Using nematodes as a screening model, the obtained nematodes were fed a culture medium containing different strains of nematodes and subjected to fat staining. The nematode fed with Lp90 had the lowest fat staining intensity, indicating the least amount of fat accumulation in its body. On the other hand, testing the cholesterol content found that it has the effect of lowering cholesterol. t is speculated that the reason may be due to its high bile salt hydrolysis enzyme activity, resulting in an increase in the amount of bile salt hydrolysis in the body. In order to supplement bile salt, the human body needs to use cholesterol to svnthesize bile salt from scratch, resulting in a decrease in cholesterol content in the body.

Lp90 has excellent tolerance and stability