Animal experiments show that BL21 can improve the antioxidant capacity of the livers of mice with alcoholic liver disease, help reduce alcohol-induced oxidative stress, reduce inflammation, improve liver damage, and regulate bifidobacteria and Akkermansia in the intestinal flora. The relative abundance of Bacillus and other bacterial genera restored the balance of intestinal flora and improved alcoholic liver disease in mice.

It has strong resistance to gastric acid and bile salts, can inhibit common pathogenic bacteria, and regulate intestinal flora. Studies have found that Pediococcus pentosaceus alleviates ethanol-induced liver damage by regulating intestinal microbiota and short-chain fatty acid metabolism.

Able to tolerate gastric acid and bile, it can secrete lactic acid to lower the pH in the intestine, thereby inhibiting pathogenic bacteria such as Staphylococcus aureus, Escherichia coli and Salmonella, and can improve the structure of the intestinal flora by increasing the relative abundance of beneficial bacteria, work synergistically with hangover-relieving and liver-protecting strains.

Animal experiment results show that WKB99 can significantly reduce the alanine aminotransferase and triglyceride contents in the livers of high-fat mice, regulate liver metabolic function, and has the potential to relieve hangover and protect the liver.