Lacticaseibacillus casei LC89 exerts antidiabetic effects through regulating hepatic glucagon response and gut microbiota in type 2 diabetic mice

Introduction

Remodeling the intestinal microbiota is helpful for the treatment of T2DM. Probiotics can regulate the gut microbiota in the intestinal tract through colonization. Clinical studies have shown that Lacticaseibacillus casei regulates and stabilizes the intestinal microbiota of adult and elderly subjects. This study aims to explore the improvement of LC89 on diabetes mice and its mechanism.

Study Design

Main Results

1. LC89 reduced FBG, blood lipids, insulin resistance, and inflammation

2. LC89 alleviated the pancreatic and liver injury

NC                           DC                       LC89

3. LC89 balanced the gut microbiota

Conclusion

Lacticaseibacillus casei LC89 alleviated the symptoms of diabetes by improving fasting blood glucose, reducing blood lipids and serum insulin, and reducing inflammation, protecting the pancreas and liver, restoring the intestinal flora disorder caused by diabetes, and improving body health.