Wecare Probiotics Upgrade Program on anti-Helicobacter pylori

Meat skewers on the barbecue grill niggling, and a wide variety of snacks, snack stalls ...... Normally, in order to satisfy our appetite, our stomachs bear too much pressure. Gastritis, peptic ulcer and even stomach cancer are the protests of our stomach. The "culprit" of these gastric diseases is Helicobacter pylori (HP), which is recognized by the World Health Organization (WTO) as a class I gastric cancer carcinogen.

On June 3, the Institute of Infectious Disease Prevention and Control of the Chinese Center for Disease Control and Prevention (CDC) released China's first white paper in the field of prevention and control of Helicobacter pylori infection, "Prevention and Control of Helicobacter pylori Infection in China".

The white paper lists microecological agents as a new pathway for the eradication treatment of HP infection, and writes, "The process of eradication treatment may result in intestinal flora disorders that lead to diarrhea, and microecological agents can be taken to prevent and correct the flora imbalance."

Anti-pylori difficulties :

Helicobacter pylori is able to colonize and cause disease in the human stomach, and the current clinical treatment for H. pylori mainly uses antibiotic combinations and is prone to recurrence.

● The misuse of antibiotics has led to an increase in HP resistance to antibiotics, which in turn has resulted in a long treatment cycle and a high recurrence rate of HP.

● Bismuth is neurotoxic, limiting its use in the elderly and children.

● Antibiotic treatment will lead to the disruption of the micro-ecological balance in the stomach, which also provides an opportunity for the recurrence of HP.

● When the body is affected by chronic diseases, cancer, surgery or radiation, or the imbalance of gastrointestinal flora caused by irrational application of antibiotics, HP will become the dominant bacteria and multiply to cause disease.

Bacteria for Bacteria, All-round Anti-Pylori Upgrade

Wecpro ® Anti-Pylori Probiotic Solution

To address the difficulties in the anti-pylori process, Wecare Probiotics has launched Wecpro ® Anti-Pylori Complex Probiotic Solution, which selects advantageous patented strains such as Lactobacillus acidophilus LA05, Lactobacillus acidophilus LA85, and Lactobacillus plantarum Lp05, which are able to inhibit the growth and proliferation of various subtypes of H. pylori, inhibit H. pylori's adherence to gastric epithelial cells, and reduce inflammatory reactions caused by different subtypes of H. pylori.

Patent Research Data

●Lactobacillus acidophilus LA05 has an inhibitory effect on the growth and cell adhesion of different subtypes of Helicobacter pylori.

Growth inhibition of Helicobacter pylori of different subtypes by Lactobacillus acidophilus

Results of the effect of Lactobacillus acidophilus on the adhesion of Helicobacter pylori cells Fig

Lactobacillus acidophilus supernatant had good inhibitory effect on different subtypes of H. pylori, among which the inhibitory effect on the main genotypes cagA+ and vacA sla/m2 was the most obvious, with the diameter of the inhibitory circle of 23 .61±0.31 and 25 .72±0.23, respectively, and had an inhibitory effect on the adhesion of H. pylori cells.

●Lactobacillus acidophilus LA05 in combination with Lactobacillus plantarum Lp05 for synergistic effects

Inhibition of Helicobacter pylori by different strains or combinations of strains

The strain combination obtained by compounding Lactobacillus acidophilus LA05 with Lactobacillus plantarum Lp05 showed improved results in inhibiting the growth of H. pylori as compared to the two strains alone, suggesting an unexpected synergistic effect of the two strains in inhibiting the growth of H. pylori.

●Lactobacillus acidophilus LA85 has a high resistance to gastrointestinal stress and a significant inhibitory effect on conditionally pathogenic bacteria

Inhibition of pathogenic bacteria by Lactobacillus acidophilus LA85 fermentation solution

Lactobacillus acidophilus LA85 has high resistance to gastrointestinal stress, has obvious inhibitory effect on conditionally pathogenic Escherichia coli, Salmonella and Staphylococcus aureus, is sensitive to common antibiotic drugs, does not have drug resistance, and the strain has a fast growth rate, short growth cycle, high number of viable bacteria, which can effectively regulate the immune response of the body.

●Lactobacillus acidophilus LA85 and Bifidobacterium lactis BLa80 both inhibit the growth of Helicobacter pylori and reduce its urease activity

Diameter of the circle of inhibition against Helicobacter pylori infection

Probiotic strains reduce the uricase activity of Helicobacter pylori

Both strains, Lactobacillus acidophilus LA85 and Bifidobacterium lactis BLa80, were able to inhibit the growth of H. pylori, and the diameters of the H. pylori inhibitory circle were 25 mm and 16 mm, respectively, and also had the ability to reduce its urease activity and the ability to reduce the adherence of H. pylori to the AGS cells, respectively.

●Probiotic blend consisting of Lactobacillus acidophilus LA85 and Bifidobacterium lactis BLa80 inhibits the level of inflammatory factors after H. pylori infection and relieves the inflammation caused by H. pylori infection

Improvement of gastrointestinal symptoms in patients before and after the experiment

The mixed probiotic combination of Lactobacillus acidophilus LA85 and Bifidobacterium lactis BLa80 can significantly alleviate gastrointestinal symptoms in patients with H. pylori infection, and markedly improve the level of inflammatory factors in patients with H. pylori-associated chronic gastritis, as verified by a small population-based trial of H. pylori infection.

Intelligent Manufacturing of High Quality Probiotics

Wecare Probiotics makes the world free of pylorus

As a leading supplier of probiotic strain ingredients, Wecare Probiotics has launched Wecpro ® Anti-Pylori Complex Probiotic Solution, which is a patented, superior strain, scientifically formulated to be highly active and stable, and can be used in the preparation of medicines for the prevention and/or alleviation of gastrointestinal disorders caused by Helicobacter pylori infections without causing adverse reactions or resistance to the pathogen, which is of great value in applications. It has important application value.

The company has always insisted on quality and technology, focusing on the bottlenecks in the science and technology and industrialization of probiotic strains, and possessing highly efficient equipment ranging from small-scale pilot tests to pilot tests to large-scale intelligent manufacturing, as well as leading production facilities and supply chain systems in the probiotic industry, which can ensure the supply of highly stable and active probiotic strains from raw materials to finished products, and make the whole process of product processing traceable.

Research, production, application and intelligent manufacturing base of Wecare Probiotics strain

Data source of invention patents:

1, Application of Lactobacillus acidophilus LA85 and Bifidobacterium lactis BLa80 in the inhibition of Helicobacter pylori (CN202111614935.5 pending)

2, A kind of Lactobacillus acidophilus against Helicobacter pylori infection and its culture method and application (ZL202210413078.0)