WecLac® Probiotic Strain with Acidophilic Characteristics, LA85 and Its Applications

Research Abstract:

[1] Lactobacillus acidophilus LA85, isolated from collected samples of the healthy human intestinal tract, exhibits strong inhibitory effects on common conditionally pathogenic bacteria such as Escherichia coli, Salmonella, and Staphylococcus aureus. The strain demonstrates a high resistance to gastrointestinal stress, characterized by rapid growth, short life cycle, and a high count of viable cells. It can modulate the levels of immune-related cytokines in the body, highlighting its immunoregulatory function.

[2] Currently, this strain is preserved at the General Microbiological Culture Collection Center of the China General Microbiological Culture Collection Management Committee, with the accession number CGMCC No. 21802.

[3] The LA85 bacterial powder is produced using patented technologies that involve cultivation, enrichment, and freeze-drying. It appears as a milky white or light yellow powder and finds extensive applications in the fields of food, dietary supplements, and pharmaceuticals.

Strain Function Study:

● Wecare Probiotics' Lactobacillus acidophilus LA85 exhibits notable inhibitory effects against conditionally pathogenic bacteria.

The inhibitory effects of Lactobacillus acidophilus LA85 on Escherichia coli, Salmonella, and Staphylococcus aureus are evident.

● Wecare Probiotics' Lactobacillus acidophilus LA85 Gastrointestinal Tolerance

After exposure to artificial gastric and intestinal fluids for 3 hours, Lactobacillus acidophilus LA85 maintains a high survival rate, indicating its excellent tolerance to gastrointestinal fluids.

● Wecare Probiotics Lactobacillus acidophilus LA85 Growth Curve and pH Curve

Lactobacillus acidophilus LA85 displays characteristics of rapid growth, a short growth cycle, and a high count of viable cells, as depicted in its growth curve and pH curve.

● Wecare Probiotics Lactobacillus acidophilus LA85 Growth Curve and pH Curve

Lactobacillus acidophilus LA85 significantly enhances the production of IgA cells in mice and increases the levels of the immune factor IL-12 in the serum. Simultaneously, it reduces the levels of IFN-γ, showcasing its immunomodulatory properties and its potential role in improving human health.

Research Conclusion:

Probiotics play a crucial role in regulating the balance of the intestinal microbiota, maintaining the integrity of the intestinal barrier, defending against the adhesion and invasion of intestinal pathogens, and stimulating host cellular and humoral immune responses. The patented strain of Lactobacillus acidophilus LA85 from Wecare Probiotics exhibits a high resistance to gastrointestinal stress, significantly inhibits the growth of Escherichia coli, Salmonella, and Staphylococcus aureus, and effectively modulates the host immune system. Products prepared from this strain can be widely applied in functional microbial agents, food, dietary supplements, or pharmaceuticals.