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Home > Products > WecLac^® Individual Clinical Strains > Lactobacillus acidophilus

Lactobacillus acidophilusLA85

Potency

300B CFU/g

Source of Strain

Healthy infant intestines

Deposit Number

PTA-126815(ATCC) No.21802(CGMCC)
DSM34693(DSMZ)

Functions

Gastrointestinal Health
Emotional Health
Metabolic Health
Maternal & Child Health
Immune Health
Oral Health

References

[1]Guo X, Guo A, Li E. Biotransformation of two citrus flavanones by lactic acid bacteria in chemical defined medium. Bioprocess Biosyst Eng. 2021 Feb;44(2):235-246. doi: 10.1007/s00449-020-02437-y. Epub 2020 Sep 4. PMID: 32888093.

[2]Zhao TS, Xie LW, Cai S, Xu JY, Zhou H, Tang LF, Yang C, Fang S, Li M, Tian Y. Dysbiosis of Gut Microbiota Is Associated With the Progression of Radiation-Induced Intestinal Injury and Is Alleviated by Oral Compound Probiotics in Mouse Model. Front Cell Infect Microbiol. 2021 Oct 25;11:717636. doi: 10.3389/fcimb.2021.717636. PMID: 34760714; PMCID: PMC8573182.

[3]Wang Z, Feng Y, Yang N, Jiang T, Xu H, Lei H. Fermentation of kiwifruit juice from two cultivars by probiotic bacteria: Bioactive phenolics, antioxidant activities and flavor volatiles. Food Chem. 2022 Mar 30;373(Pt B):131455. doi: 10.1016/j.foodchem.2021.131455. Epub 2021 Oct 23. PMID: 34731808.

[4]Xue L, Li Z, Xue J, Wang H, Wu T, Liu R, Sui W, Zhang M. Lactobacillus acidophilus LA85 ameliorates cyclophosphamide-induced immunosuppression by modulating Notch and TLR4/NF-κB signal pathways and remodeling the gut microbiota. Food Funct. 2022 Aug 1;13(15):8107-8118. doi: 10.1039/d1fo04331e. PMID: 35793105.

[5]Han M, Liao W, Dong Y, Fei T, Gai Z. Sustained ameliorative effect of Lactobacillus acidophilus LA85 on dextran sulfate sodium-induced colitis in mice. J Food Sci. 2023 Aug 7. doi: 10.1111/1750-3841.16723. Epub ahead of print. PMID: 37548631.

[6]Dong Y, Han M, Fei T, Liu H, Gai Z. Utilization of diverse oligosaccharides for growth by Bifidobacterium and Lactobacillus species and their in vitro co-cultivation characteristics. Int Microbiol. 2023 Nov 9. doi: 10.1007/s10123-023-00446-x. Epub ahead of print. PMID: 37946011.

[7]Rui W, Zhong S, Li X, Tang X, Wang L, Yang J. Evaluating the Role of Postbiotics in the Modulation of Human Oral Microbiota: A Randomized Controlled Clinical Trial. Probiotics Antimicrob Proteins. 2024 Mar 19. doi: 10.1007/s12602-024-10238-y. Epub ahead of print. PMID: 38502383.

[8]Wu, CaiyunLi, TianlinQi, JingJiang, TianXu, HuaideLei, Hongjie.Effects of lactic acid fermentation-based biotransformation on phenolic profiles, antioxidant capacity and flavor volatiles of apple juice[J].LWT-Food Science & Technology, 2020, 122.

Introduction

Bristol stool types

To evaluate the efect of probiotics as food supplements on reducing diarrhea causing by antibiotics
Stool morphology and quality of life were measured according to the Bristol type stools and gastrointestinal quality of life(GlQLl)questionnaires
It shows a summary of the results of the study subjects' quality of life survey. In the assessment of quality of life using the GlQLl questionnaire, significantly higher scores were observed in the probiotic group in the pleasure of eating (p = 0.043) and in activities of daily living (p = 0.033).

Subjects

LA85 has the ability to regulate the Notch signaling pathway and promote intestinal mucosal repair. Additionally, it enhances the immune response of the body through the TLR4/NF-kB signaling pathway.

New antibacterial use of LA85 and its application in the preparation of drugs to relieve ElEC carrhea

LA85 has a significant inhibitory effect on the growth of ElEC.

LA85 intervention could reduce the weight loss of mice caused by ElEC infection to a certain extent, and was conducive to weight recovery,

The result shows the intervention of LA85 can increase the a-diversity index of intestinal flora in mice, which can increase the microbial diversity in the intestinal tract of mice.

LA85 can effectively regulate the level of cytokines, reduce the content of pro-inflammatory factors in the colon tissue, and increase the content of anti-inflammatory factors, thereby alleviating the intestinal invasive infammation and regulating the immunity of mice.

Improving diarrheal state and Bristol stool types

In this study, diarrhea occurred at a lower frequency in the probiotic group in comparison with placebo (6 vs 2 cases), and also delaving its appearance (3.5 vs 3.0 days) and with a shorter duration (3.5 vs 3.8 davs). in the PP population, includina the patients with full adherence, only one case of diarrhea was reported in the probiotic group. in the evolution of stools, more consistency has been detected across the treatment in the probiotic group, with a statistically significant decrease in the percentage of patients with the most dehydraing type 7 stools (2.4% vs 19.5%, thus highlighting the effect of probiotic to promote bowel regularity during the antibiotic period.

Characteristics of diarrheal state in both groups

Evolution of Bristol type stools during the study period in both groups

Bristol scale evolution by treatment

Improving gastrointestinal quality of life (GlQLl) and overall patient satisfaction

GlQLl questionnaire results

It shows a summary of the results of the study subjects" quality of life survey. in the assessment of quality of life using the GlQLl questionnaire, significantly higher scores were observed in the probiotic group in the pleasure of eating (p = 0.043) and in activities of daily living (p = 0.033).

LA85 ameliorates cyclophosphamide-induced immunosuppression by modulating Notch and TLR4/NF-kB signal pathways and remodeling the gut microbiota.

LA85 exerts a pronounced effect on enhancing the beta diversity of the gut microbiota and inducing structural changes in the composition of qut microbial communities.

Inhibit the growth of pathogenic bacteria; prevent and improve periodontitis

LA85 has a significant inhibitory effect on common pathogens, making probiotics the dominant bacteria, and optimize the oral environment. Among them, the constituent bacterium Lactobacilus acidophilus LA85 and its inactivated bacteria have an adhesion effect on oral epithelial cells, which can compete with pathogenic bacteria for binding sites on the mucosa surface, reducina the colonization of pathoaenic bacteria. and for oral pathodenic bacteria aums Porohvromonas has adhe-sion antagonism (as shown in the figure below) to achieve oral health care.