SCI/Patent Supported
Potency
300B CFU/g
Source of Strain
Healthy infant intestines
Deposit Number
PTA-126815(ATCC) No.21802(CGMCC)
DSM34693(DSMZ)
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To evaluate the efect of probiotics as food supplements on reducing diarrhea causing by antibiotics
Stool morphology and quality of life were measured according to the Bristol type stools and gastrointestinal quality of life(GlQLl)questionnaires
It shows a summary of the results of the study subjects' quality of life survey. In the assessment of quality of life using the GlQLl questionnaire, significantly higher scores were observed in the probiotic group in the pleasure of eating (p = 0.043) and in activities of daily living (p = 0.033).
LA85 has the ability to regulate the Notch signaling pathway and promote intestinal mucosal repair. Additionally, it enhances the immune response of the body through the TLR4/NF-kB signaling pathway.
LA85 has a significant inhibitory effect on the growth of ElEC.
LA85 intervention could reduce the weight loss of mice caused by ElEC infection to a certain extent, and was conducive to weight recovery,
The result shows the intervention of LA85 can increase the a-diversity index of intestinal flora in mice, which can increase the microbial diversity in the intestinal tract of mice.
LA85 can effectively regulate the level of cytokines, reduce the content of pro-inflammatory factors in the colon tissue, and increase the content of anti-inflammatory factors, thereby alleviating the intestinal invasive infammation and regulating the immunity of mice.
In this study, diarrhea occurred at a lower frequency in the probiotic group in comparison with placebo (6 vs 2 cases), and also delaving its appearance (3.5 vs 3.0 days) and with a shorter duration (3.5 vs 3.8 davs). in the PP population, includina the patients with full adherence, only one case of diarrhea was reported in the probiotic group. in the evolution of stools, more consistency has been detected across the treatment in the probiotic group, with a statistically significant decrease in the percentage of patients with the most dehydraing type 7 stools (2.4% vs 19.5%, thus highlighting the effect of probiotic to promote bowel regularity during the antibiotic period.
Bristol scale evolution by treatment
It shows a summary of the results of the study subjects" quality of life survey. in the assessment of quality of life using the GlQLl questionnaire, significantly higher scores were observed in the probiotic group in the pleasure of eating (p = 0.043) and in activities of daily living (p = 0.033).
LA85 exerts a pronounced effect on enhancing the beta diversity of the gut microbiota and inducing structural changes in the composition of qut microbial communities.
LA85 has a significant inhibitory effect on common pathogens, making probiotics the dominant bacteria, and optimize the oral environment. Among them, the constituent bacterium Lactobacilus acidophilus LA85 and its inactivated bacteria have an adhesion effect on oral epithelial cells, which can compete with pathogenic bacteria for binding sites on the mucosa surface, reducina the colonization of pathoaenic bacteria. and for oral pathodenic bacteria aums Porohvromonas has adhe-sion antagonism (as shown in the figure below) to achieve oral health care.