Star Probiotics-WecLac Bifidobacterium Longum BL21

No.1 strain advantage

Health efficacy verification

1、Gut health

Bifidobacterium longum BL21 can significantly alleviate colorectal cancer, reduce intestinal stress damage, and improve the microecology of intestinal flora by regulating the expression of apoptosis-related genes in colorectal tumor cells and reducing the number of colorectal tumors in mice. environment, maintain intestinal health, and have great potential in preparing products to prevent or treat colorectal cancer.

Relevant clinical/documents/patents

1. Clinical research Prospective phase II clinical study plan for the prevention/treatment of radiation-induced intestinal injury with probiotic Bifidobacterium longum BL21

2. Clinical study Constipation: Based on a randomized, double-blind, placebo-controlled trial, evaluate the safety and effectiveness of Bifidobacterium longum BL21 in relieving chronic constipation in adults.

3. Application of Bifidobacterium longum BL21 and bacterial agents containing it in the preparation of products for preventing, alleviating or treating colorectal cancer

4. Dysbiosis of Gut Microbiota Is Associated With the Progression of Radiation-Induced Intestinal Injury and Is Alleviated by Oral Compound Probiotics in Mouse Model. Front Cell Infect Microbiol.

2、Beauty and anti-aging

Bifidobacterium longum BL21 has a good effect on the scavenging rate of superoxide free radicals and hydroxyl free radicals. It can produce high levels of extracellular polysaccharides, maintain the balance of intestinal flora, inhibit the growth of harmful bacteria, and delay the aging of the human body.

Relevant clinical/documents/patents

1. A kind of lactobacillus BL21 with high production of extracellular polysaccharide and its preparation method and application

2. An anti-aging probiotic preparation and preparation method

3、Liver health

Bifidobacterium longum BL21 can reshape Rosette and phospholipid serine levels, improve intestinal diseases and liver metabolic abnormalities caused by high-fat diet. Products with BL21 strain and LRa05 strain as the main functional ingredients can significantly reduce serum and It has good application prospects by improving the levels of TC, LDL and TG in the liver, increasing the levels of HDL in serum and liver, and reducing body fat, especially perirenal fat or abdominal wall fat.

●Relevant clinical/documents/patents

1. Bifidobacterium longum subsp. longum Remodeled Roseburia and Phosphatidylserine Levels and Ameliorated Intestinal Disorders and liver Metabolic Abnormalities Induced by High-Fat Diet.

2. A compound probiotic that inhibits fat accumulation and its application

4、metabolic health

The combination of Bifidobacterium longum BL21 strain and Lactobacillus rhamnosus LRa05 strain can significantly reduce the serum levels of ALT, AST, etc. in patients with type II diabetes; reduce serum inflammatory factor levels; significantly reduce elevated fasting blood glucose levels and oral glucose The area under the curve in the tolerance test can prevent, treat, and alleviate type II diabetes. BL21 can effectively reduce the content of uric acid in the blood, alleviate the side effects of hyperuricemia, increase the diversity of intestinal flora, and enhance the intestinal mucosal barrier.

●Relevant clinical/documents/patents

1. A microbial composition for preventing or treating type II diabetes and its preparation method and application

2. Probiotic composition capable of alleviating hyperglycemia and preparation method thereof

3. The antidiabetic effects of Bifidobacterium longum subsp. longum BL21 through regulating gut microbiota structure in type 2 diabetic mice. Food Funct.

4. Probiotic composition with the effect of alleviating high uric acid and its application

5、weight management

Bifidobacterium longum BL21 can supplement the body with probiotics, maintain the balance of intestinal flora, improve the body's immunity, effectively control body weight, inhibit fat accumulation, reduce the weight of mice fed a high-fat diet, and improve blood lipid levels.

●Relevant clinical/documents/patents

1. Clinical study: Effect of Bifidobacterium longum BL21 on low-grade inflammation, microbiota and risk factors of metabolic syndrome in obese children

2. A compound probiotic that inhibits fat accumulation and its application

3. A sucrose-free probiotic yogurt with weight control effect and its preparation method

No.2 strain advantage

High yield of extracellular polysaccharides and antioxidant power

Bifidobacterium longum BL21 can produce high levels of extracellular polysaccharides, has free radical scavenging and antioxidant properties, and has strong tolerance. It can successfully colonize the intestines and maintain high activity. It can regulate intestinal flora and improve constipation.

1. High-yield extracellular polysaccharide

Bifidobacterium longum BL21 can high-produce extracellular polysaccharides that can inhibit the synthesis of melanin in cells and reduce the number of skin spots. The extracellular polysaccharides can be used to prepare external preparations for improving skin color.

Comparison of electron microscopy pictures of extracellular polysaccharides produced by Bifidobacterium longum BL21 and control bacteria

Further investigation of the effect of the extracellular polysaccharide produced by the bacterium on the number of spots and melanin found that it can significantly reduce the number of spots and chloasma, and reduce the melanin value of the skin. Therefore, it can be used to manufacture cosmetics, skin care products, and various skin external preparation compositions.

Effects of extracellular polysaccharides on spots, chloasma and melanin

2. Antioxidant capacity

The presence of a small amount of H2 was detected during the fermentation process of Bifidobacterium longum BL21. The hydrogen produced endogenously (that is, produced by intestinal flora) has antioxidant, anti-apoptotic, anti-inflammatory, cell protection and other effects. In addition, in addition to testing the hydrogen production performance to characterize the strain's antioxidant properties, BL21 also has excellent performance in scavenging superoxide radicals, hydroxyl radicals (·OH) and superoxide dismutase (SOD), further indicating that Bifidobacterium longum BL21 It has potential application value in antioxidant.

Lactobacillus helveticus LH76 and Bifidobacterium longum BL21 fermentation gas detection

Performance values of strains scavenging superoxide radicals, hydroxyl radicals and SOD activity

Data source related patents: A lactobacillus BL21 with high production of extracellular polysaccharides and its preparation method and application (ZL201510217639.X)

3、High tolerance

Bifidobacterium longum powder BL21 was exposed to simulated gastric acid pH 3.0 for 2 hours, and the survival rate reached 72%. When exposed to simulated bile salt concentration of 0.3% for 2 hours, the survival rate reached 78%, indicating that it has good tolerance.

Bifidobacterium longum BL21 tolerance test

No.3 strain advantage

Wider range of applications

Bifidobacterium longum BL21 is a strain with high production of extracellular polysaccharides. It is isolated from the intestinal tract of healthy infants. BL21 has excellent acid and bile salt resistance and good cell adhesion ability. Its efficacy and prospects in food, health care and medical treatment It has been valued by more people and can also be used to manufacture cosmetics, skin care products and various skin external preparation compositions.

No.4 strain advantage

Enterprise qualification certification

Focus on value recognition

We offer you Lactobacillus rhamnosus LRa05 with activity ≥800 billion CFU/g.

Service Hotline: 400-8518-553

Some literature sources:

1. A lactobacillus BL21 with high production of extracellular polysaccharides and its preparation method and application (ZL201510217639.X)

2. An anti-aging probiotic preparation and preparation method (ZL201610809684.9)

3. Probiotic composition and its application with the effect of alleviating high uric acid (ZL201911330780.5)

4. A microbial composition for preventing or treating type II diabetes and its preparation method and application (ZL202110839317.4)

5. A compound probiotic that inhibits fat accumulation and its application (CN202210448054.9 pending)

6. Application of Bifidobacterium longum BL21 and bacterial agents containing it in the preparation of products for preventing, alleviating or treating colorectal cancer (CN202210449134.6 pending)

7. A sucrose-free probiotic yogurt with weight control effect and its preparation method (CN202211272786.3 pending)

8. Probiotic composition capable of alleviating hyperglycemia and its preparation method (CN201911346165.3 pending)

9. A lactic acid bacterium with high folic acid production, its preparation method and application (CN202110225495.8 pending)